Thailand Hair Transplant Center

Highly skilled | Meticulous | Conscientious

Thai language button

DRUGS FOR 

MALE PATTERN HAIR LOSS

When it comes to remedies for men’s hair loss, numerous alternative non-medical products claim to stop hair loss or promote hair growth. After trying multiple products, you may find that none have worked for you.

To be effective, alopecia must be addressed at its root cause. Different individuals have various underlying issues that contribute to hair loss.

There is no single product that works for everyone experiencing hair loss. In fact, while there is no cure, several treatment options are available; thus, medications should be used to manage hair loss rather than to cure it.

What causes men’s hair loss ?

Different medications are necessary to manage each of these conditions to control hair loss or thinning.

Currently, there are only 2 genetic hair loss medications approved by U.S. FOOD AND DRUG ADMINISTRATION (FDA). They are 

-FINASTERIDE 1 mg. 

-MINOXIDIL TOPICAL SOLUTION

Additionally, there are alternative hair loss treatments that many doctors use for genetic alopecia, but these have not yet been approved by the FDA. These include:

-LOW-DOSE MINOXIDIL (ORAL FORM)

-DUTASTERIDE

-TOPICAL FINASTERIDE

-SAW PALMETTO

FINASTERIDE 1 MG. 

Finasteride 1 mg.

Finasteride 1 mg was initially marketed under the brand name Propecia. Now that the patent has expired, many generic versions of Finasteride are available on the market at a much lower cost. As a result, many people have switched to the more affordable generic Finasteride instead of continuing with Propecia. 

What is FINASTERIDE ?

FINASTERIDE is an oral medication most prescribed for male pattern hair loss. Finasteride can reverse hair loss by resuscitating and fortifying the existing dormant hair follicles so they can regrow new hair. 

In fact, Finasteride does not grow hair as many people may think, it just makes regrown hair shafts bigger and thicker which in turn make the bald/thinning area look denser for the same amount of hair follicles.

How does FINASTERIDE work ?

There are 2 main factors that are associated with hair loss, Genetics and DHT (DIHYDROTESTOSTERONE), a byproduct of testosterone in men. 

Together they are the main reason to cause balding in men. Without one or the other, it does not cause any significant balding and hair would fall out at a much slower rate.

LEFT PICTURE  Male testosterone is usually coverted to DHT by 5-AR enzyme. DHT causes balding in men with genetic susceptibilities by weakening hair follicles— causing them to become smaller, to produce thinner hair shafts, and to succumb eventually. Without genetic factors, DHT alone does not cause balding. 

RIGHT PICTURE Finasteride works as a 5-AR inhibitor to block testosterone from transforming to DHT, which helps slow hair loss in men with genetic factors.

STERZAR and PROSTAT-1 (Finasteride 1mg) are two of the many generic alternatives to Propecia, offering the same treatment at a fraction of the cost—typically 3 to 5 times less. Since Finasteride is often used long-term, switching to these generics can be a more cost-effective option for you. 

 Does FINASTERIDE actually work ?

Each individual responds differently to the medication, leading to varying results. However, Finasteride has been shown to be 66-88% effective in reducing and slowing hair loss for most users. 

__________________

Is FINASTERIDE available over-the-counter? 

In the U.S., Finasteride (Propecia) is available only by prescription. However, in some other countries, it may be sold as an over-the-counter medication. 

__________________

How much does FINASTERIDE 1mg. cost?

Propecia (the brand name) typically ranges from $50 to $110 per box (28 tablets), while generic Finasteride is usually priced between $13 and $20 per box (28-30 tablets). 

_________________

 Dosage

The recommended dosage is one 1-mg tablet daily. For maximum effectiveness, it is best to take it around the same time every day. 

It must be taken for at least 6-12 months before you can see any results. 

________________________

 Can FINASTERIDE regrow hair at the receding hairline ?

Finasteride works best for hair loss on the top of the head and the crown area. 

For unknown reasons, Finasteride is not effective for the receding hairline where hair transplantation can offer the greatest improvement.

________________________

What happens if I stop taking FINASTERIDE ?

After using Finasteride long enough to see the regrowth, you need to continue using it indefinitely or as long as your body is still producing testosterone to retain the benefits. Discontinuing the use of it results in returning hair loss.

To put this into perspective, if a man had permanently lost 10 hairs a day due to his hair loss problem before taking Finasteride, he would have lost 3,650 hairs in a year or 7,300 hairs in 2 years. But he has been taking Finasteride in the past 2 years so Finasteride has been keeping those 7,300 hairs in tact. 

If he stops taking Finasteride now, those 7,300 hairs will fall out as many as 100-200 hairs per day in the next 2-8 weeks which will bring him back to the point he would have been had he never taken Finasteride.

________________________

Side effects

1.Loss of sexual desire and erectile dysfunction. Less than 2% of people taking Finasteride are affected. 

In a 2019 medical research, the survey found no difference in sexual side effects among people who used finasteride for hair loss. Read more

From our 20 years of experience in this field, we find that sexual side effects of Finasteride are rare. Most times people tend to have judgmental thoughts due to the coincidental occurrences. 

When the sexual side effects happen anytime after taking the medication, people usually blame it by overlooking other possible factors that could have caused them sexual dysfunction whether they take the medication or not. 

Those factors include age, obesity, alcohol consumption, smoking, binge eating, bedtime, lack of exercise, anxiety, or even spousal relationship.

2.Decreased volume of ejaculate and a decrease of sperm count in some men. This is a typical finding in men fertility. It is not recommended for men who are in the reproductive ages and have low sperm count (Oligospermia)

3.Swelling or tenderness of the breasts.

4.Depression

All of these side effects may subside at any time or may persist even after discontinuing the use of this medication.

5.Finasteride is not usually prescribed for women; women who may be pregnant are at risk for congenital defect in the unborn child. 

However, some doctors prescribed Finasteride for post-menopausal women with inherited hair loss and found that it worked well for them.

6.Children under 18 years of age should not take Finasteride since it decreases male growth hormones, substances essential for children to grow and develop.

5 tips to prevent sexual dysfunction

1.Regularly go to bed by 10:00 P.M. in order to benefit from growth hormone release.

2.Do aerobic exercise for 45-60 minutes daily, 4-5 days a week.

3.Skip or eat a small portion of dinner before 5:00 P.M. No eating or snacking afterwards before bedtime except for drinking water.

4.Stop smoking if you smoke.

5.Get medical info written by medical professionals from trusted websites rather than from any individuals’ comments, hair forums, or blogs, which are anecdotal, written by people who do not have medical knowledge. 

The medical professionals are more likely to give factual, unbiased assessment of benefits and drawbacks based on research and studies being done on a number of people.

When you follow these tips, chances of having sexual dysfunction will be minimal.

FINASTERIDE before & after

These before-and-after pictures show the result you can expect to see after 5 months of using Finasteride consecutively. It can take up to 2 years to see the maximum result.

MINOXIDIL 

TOPICAL SOLUTION

What is Minoxidil ?

Minoxidil was originally developed in the 1960s as a vasodilator to treat high blood pressure. During clinical trials, researchers observed an unexpected side effect: increased hair growth. This led to the development of minoxidil as a topical treatment for androgenetic alopecia (pattern baldness) and other forms of hair loss. 

Minoxidil Topical solution was first introduced under the brand name Rogaine and remains the only FDA-approved topical treatment for hair loss. 

So it is mainly recommended for women’s hair loss and to be used with Finasteride as a combination treatment for men’s hair loss. Read more

TIPS

Alternative Medications 

LOW-DOSE MINOXIDIL

Low-dose oral minoxidil (LDOM) is minoxidil in pill form, taken at doses much lower than those used for blood pressure regulation. The concept behind using low doses of oral minoxidil for hair loss is to provide the same therapeutic benefits—stimulating hair growth—while reducing the risk of adverse effects.

The typical dosage for oral minoxidil used to treat hypertension is 10–40 mg per day. In contrast, low-dose oral minoxidil for hair loss is often prescribed at much smaller doses, ranging from 0.25 mg to 2.5 mg per day. This lower dosage significantly reduces the likelihood of side effects while still promoting hair growth.

How Does Low-Dose Minoxidil Work?

Minoxidil is believed to stimulate hair follicles by increasing blood flow to the scalp and promoting hair follicle activity. It works by:

________________________

Benefits of Low-Dose Oral Minoxidil

________________________

Potential Side Effects

Although low-dose oral minoxidil is generally well-tolerated, it’s important to be aware of potential side effects. These may include:

________________________

Who Can Benefit from Low-Dose Minoxidil?

Low-dose minoxidil is an option for individuals with various types of hair loss, including men and women with androgenetic alopecia (male and female pattern baldness). It can also be useful for patients who have not responded well to topical minoxidil or those who experience scalp irritation with the topical form.

Some dermatologists also recommend low-dose oral minoxidil for people who prefer a more convenient treatment approach or for those with widespread hair loss that may not be well-covered by topical application.

________________________

Consulting a Healthcare Professional

Before starting any hair loss treatment, it’s important to consult with a dermatologist or healthcare provider to determine the best course of action. They can assess whether low-dose minoxidil is appropriate based on the individual’s medical history and type of hair loss. Blood pressure monitoring may also be necessary during treatment, especially for individuals with underlying cardiovascular conditions.

________________________

Conclusion

Low-dose oral minoxidil is an emerging and promising option for treating hair loss. It offers a convenient and effective alternative for individuals who may not respond well to topical treatments or who prefer oral medication. While it has a favorable safety profile, it’s crucial to work with a healthcare provider to ensure proper use and minimize the risk of side effects. As research continues, low-dose minoxidil may become a more widely accepted treatment for hair loss in both men and women.

DUTASTERIDE

Dutasteride is a medication initially approved by the FDA for the treatment of benign prostatic hyperplasia (BPH), also known as an enlarged prostate. It is part of a class of drugs called 5-alpha-reductase inhibitors. These drugs work by inhibiting the conversion of testosterone to dihydrotestosterone (DHT), a hormone that contributes to both prostate enlargement and hair loss.

________________________

How Does Dutasteride Work for Hair Loss?

Dutasteride targets hair loss by reducing levels of DHT, a key factor in male pattern baldness. Hair follicles sensitive to DHT shrink over time, leading to thinner, weaker hair, and eventually stopping hair growth. By lowering DHT levels, Dutasteride helps prevent this follicular shrinkage, allowing hair to grow thicker and stronger.

While Finasteride, another popular 5-alpha-reductase inhibitor, also reduces DHT, Dutasteride is more potent. Dutasteride inhibits both types of 5-alpha-reductase enzymes (Type 1 and Type 2), whereas Finasteride only inhibits Type 2. This results in Dutasteride lowering DHT levels by more than 90%, compared to around 70% with Finasteride.

________________________

Effectiveness of Dutasteride for Hair Loss

Studies have shown that Dutasteride is highly effective for treating androgenetic alopecia. Some key findings include:

________________________

Dosage and Administration

Dutasteride targets hair loss by reducing levels of DHT, a key factor in male pattern baldness. Hair follicles sensitive to DHT shrink over time, leading to thinner, weaker hair, and eventually stopping hair growth. By lowering DHT levels, Dutasteride helps prevent this follicular shrinkage, allowing hair to grow thicker and stronger.

While Finasteride, another popular 5-alpha-reductase inhibitor, also reduces DHT, Dutasteride is more potent. Dutasteride inhibits both types of 5-alpha-reductase enzymes (Type 1 and Type 2), whereas Finasteride only inhibits Type 2. This results in Dutasteride lowering DHT levels by more than 90%, compared to around 70% with Finasteride.

________________________

Side Effects of Dutasteride

While Dutasteride is effective, it does come with some potential side effects, similar to other DHT blockers. These may include:

Though these side effects are generally rare, it's important to discuss them with your doctor before starting treatment. In many cases, side effects diminish over time or disappear after discontinuing the medication.

________________________

Conclusion

Dutasteride is a powerful and effective treatment for androgenetic alopecia, especially in men who have not had success with other treatments like Finasteride. By dramatically reducing DHT levels, it can promote hair regrowth and slow the progression of hair loss. However, as with any medication, it’s important to consider the potential side effects and consult with a healthcare provider to determine if Dutasteride is the right choice for you.

For those seeking a stronger, longer-lasting solution to hair loss, Dutasteride may be worth considering as part of a comprehensive hair restoration plan.

  ______________________

Topical Finasteride

Hair loss is a widespread issue that affects millions of people, particularly men suffering from androgenetic alopecia, also known as male pattern baldness. While oral finasteride has long been a popular treatment for hair loss, the development of topical finasteride offers a new alternative with reduced risk of systemic side effects. This innovation has piqued the interest of both patients and healthcare providers.

In this article, we’ll explore what topical finasteride is, how it works, its effectiveness, and the benefits it offers over oral finasteride.

  ______________________

The Difference Between Oral and Topical Finasteride

For many years, oral finasteride (brand name Propecia) has been one of the most commonly prescribed treatments for male pattern baldness. While effective, oral finasteride has been associated with several systemic side effects, including:

These side effects, although uncommon, have deterred some men from using oral finasteride, prompting the development of topical finasteride. Unlike the oral form, topical finasteride is applied directly to the scalp and is intended to target hair follicles without significantly affecting DHT levels throughout the body. This localized application may reduce the risk of sexual side effects and other systemic issues.

   ______________________

How Does Topical Finasteride Work?

Topical finasteride works similarly to the oral version, but with an important distinction. When applied to the scalp, it inhibits the conversion of testosterone to DHT locally, primarily within the hair follicles. This helps prevent follicular miniaturization—the process by which hair follicles shrink and produce thinner, weaker hair.

Because topical finasteride is absorbed through the skin, less of the drug enters the bloodstream, meaning it has less of an impact on overall DHT levels in the body compared to oral finasteride. This reduction in systemic absorption is thought to lower the risk of unwanted side effects.

    ______________________

Effectiveness of Topical Finasteride for Hair Loss

Studies on topical finasteride have shown promising results in treating androgenetic alopecia, with similar efficacy to the oral version:

   ______________________

Benefits of Topical Finasteride

   ______________________

Who Should Consider Topical Finasteride?

Topical finasteride may be an ideal solution for:

   ______________________

Potential Side Effects of Topical Finasteride

While topical finasteride is generally well-tolerated, some users may experience minor side effects, including:

Because the systemic absorption of topical finasteride is significantly lower, the risk of sexual side effects is much lower than with oral finasteride. However, some systemic absorption still occurs, so it’s important to monitor for any adverse effects and discuss them with your doctor.

   ______________________

Conclusion

Topical finasteride is a promising option for men seeking an effective treatment for androgenetic alopecia without the risk of systemic side effects. By targeting hair follicles directly, it offers the benefits of finasteride while reducing the likelihood of sexual dysfunction or other issues. For many, topical finasteride provides a balance between effectiveness and safety, making it a valuable tool in the fight against hair loss.

As always, it’s important to consult with a healthcare provider to determine if topical finasteride is the right treatment for your hair loss and to ensure proper usage.

   ______________________

Saw Palmetto 

Saw palmetto is a small palm tree native to the southeastern United States, particularly Florida. The berries of the tree have been used for centuries in traditional medicine to treat a variety of health conditions, including urinary and reproductive issues. Today, saw palmetto extract is widely marketed as a supplement to support prostate health and hormonal balance, with emerging interest in its role in addressing hair loss.

____________________

How Does Saw Palmetto Work ?

Hair loss, particularly androgenetic alopecia (male and female pattern baldness), is often driven by the hormone dihydrotestosterone (DHT). DHT is a byproduct of testosterone, and in genetically predisposed individuals, elevated DHT levels can shrink hair follicles, leading to thinner hair and eventual hair loss.

Saw palmetto is believed to help by blocking the enzyme 5-alpha-reductase, which is responsible for converting testosterone into DHT. By inhibiting this enzyme, saw palmetto may lower DHT levels and reduce its negative effects on hair follicles, similar to how pharmaceutical treatments like finasteride and dutasteride work. However, saw palmetto is often viewed as a gentler, more natural alternative to these prescription medications.

     ___________________

Effectiveness of Saw Palmetto

Research into saw palmetto’s efficacy for hair loss is still in its early stages, but several studies suggest it may have benefits for promoting hair growth and preventing further hair thinning.

 ____________________

Benefits of Saw Palmetto

   __________________

Who Can Benefit from Saw Palmetto?

Both men and women can potentially benefit from saw palmetto for hair loss. Since female pattern hair loss is also linked to DHT sensitivity, saw palmetto may provide benefits to women experiencing thinning hair, though research in this area is less robust than in men.

 ____________________

Dosage and Usage

Saw palmetto is available in various forms, including capsules, tablets, liquid extracts, and topical treatments like shampoos. The typical oral dosage ranges from 160 mg to 320 mg per day, depending on the formulation. Topical products containing saw palmetto are often used as part of a daily hair care routine, usually applied directly to the scalp.

   __________________

Are There Any Risks?

While saw palmetto is considered safe for most people, there are some considerations to keep in mind:

     ____________________

Conclusion

Saw palmetto extract is a promising natural option for those seeking to address hair loss, particularly androgenetic alopecia. By reducing DHT levels and supporting scalp health, saw palmetto may slow hair thinning and promote regrowth. While it may not be as powerful as pharmaceutical treatments, it offers a gentler, more holistic approach with fewer side effects.

If you’re looking for a natural alternative to combat hair loss, saw palmetto could be a valuable addition to your hair care routine. However, as with any treatment, it’s always best to consult with a healthcare provider to determine the most appropriate solution for your specific needs.

      __________________

Suggested reading